KNOWN SIDE EFFECTS OF IBUPROFEN

This includes life-threatening side effects. The reason this list is separate to the Ibuprofen article is because of the sheer length of the list of side effects. It is not enough to question whether you are suffering the side effects after one or two doses, but whether health issues now affecting your body are due to either previous or current use of Ibuprofen.

Ibuprofen affects EVERY bodily system and function in a negative way. While it is unimaginable how such a product can be so freely available, it is more concerning that the doctor’s warnings are kept separate to public information. Both are included below –

More common:

  • Abdominal pain
  • acid or sour stomach
  • belching
  • bloating
  • cloudy urine
  • decrease in amount of urine
  • decrease in urine output or decrease in urine-concentrating ability
  • diarrhea
  • difficulty having a bowel movement (stool)
  • excess air or gas in stomach or intestines
  • full feeling
  • heartburn
  • indigestion
  • itching skin
  • pain or discomfort in chest, upper stomach, or throat
  • pale skin
  • passing gas
  • nausea
  • noisy, rattling breathing
  • rash with flat lesions or small raised lesions on the skin
  • shortness of breath
  • swelling of face, fingers, hands, feet, lower legs, or ankles
  • troubled breathing at rest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Less common:

  • Abdominal cramps
  • stomach soreness or discomfort

Rare:

  • Agitation
  • back, leg, or stomach pains
  • bleeding gums
  • blistering, peeling, loosening of skin
  • blood in urine or stools
  • bloody, black, or tarry stools
  • blurred vision
  • burning feeling in chest or stomach
  • change in vision
  • chest pain
  • chills
  • clay-colored stools
  • coma
  • confusion
  • constipation
  • cough or hoarseness
  • dark urine
  • decreased urine output
  • depression
  • difficulty breathing
  • difficulty swallowing
  • dilated neck veins
  • dizziness
  • dry mouth
  • extreme fatigue
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever with or without chills
  • frequent urination
  • general body swelling
  • general feeling of tiredness or weakness
  • hair loss, thinning of hair
  • headache
  • hives or welts
  • hostility
  • impaired vision
  • increased blood pressure
  • increased volume of pale, dilute urine
  • irregular breathing
  • irritability
  • itching
  • joint or muscle pain
  • lab results that show problems with liver
  • lethargy
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle twitching
  • nosebleeds
  • painful or difficult urination
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red spots on skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of skin
  • seizures
  • severe abdominal pain, cramping, burning
  • severe and continuing nausea
  • sore throat
  • sores, ulcers, or white spots in mouth or on lips
  • stiff neck or back
  • stomach upset
  • stupor
  • swollen or painful glands
  • tenderness in stomach area
  • thirst
  • tightness in chest
  • unpleasant breath odor
  • upper right abdominal pain
  • vomiting of blood
  • vomiting of material that looks like coffee grounds
  • wheezing
  • yellow eyes and skin

Symptoms of overdose:

  • Bluish lips or skin
  • difficulty sleeping
  • disorientation
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • drowsiness to profound coma
  • hallucination
  • lightheadedness or fainting
  • mood or other mental changes
  • muscle tremors
  • not breathing
  • rapid, deep breathing
  • restlessness
  • slow or irregular heartbeat
  • stomach cramps
  • sudden fainting
  • sweating

Severity: Minor

Some of the side effects that can occur with ibuprofen may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

  • Continuing ringing or buzzing or other unexplained noise in ears
  • hearing loss
  • nervousness

Rare:

  • Crying
  • depersonalization
  • discouragement
  • dry eyes
  • dysphoria
  • euphoria
  • feeling sad or empty
  • lack of appetite
  • loss of interest or pleasure
  • mental depression
  • paranoia
  • quick to react or overreact
  • rapidly changing moods
  • runny nose
  • sleepiness or unusual drowsiness
  • sleeplessness
  • sneezing
  • stuffy nose
  • trouble concentrating
  • trouble sleeping
  • unable to sleep

 

For Healthcare Professionals

Please bear in mind these are symptoms from an OTC medication.

General

The most frequently reported adverse effects were gastrointestinal (GI) in nature and included nausea, vomiting, flatulence, and diarrhea.

The most frequently reported adverse effects were sepsis, anemia, intraventricular bleeding, apnea, GI disorders, impaired renal function, respiratory infection, skin lesions, hypoglycemia, hypocalcemia, and respiratory failure.

Gastrointestinal

Nausea (up to 57%), vomiting (up to 22%), flatulence (up to 16%), diarrhea (up to 10%)
Dyspepsia, abdominal discomfort, epigastric pain, heartburn, abdominal distress, indigestion, constipation, abdominal cramps/pain, fullness of GI tract, bloating, GI hemorrhage, melena
Abdominal distention, dyspepsia, gastritis
Peptic ulcer, perforation, hematemesis, mouth ulceration, exacerbation of colitis, exacerbation of Crohn’s disease
Dry mouth, duodenitis, esophagitis, gastric ulcer, duodenal ulcer, GI bleeding, glossitis, rectal bleeding, stomatitis, eructation, gingival ulcer, pancreatitis
GI disorders non-necrotizing enterocolitis (22%)
Necrotizing enterocolitis, intestinal perforation
Abdominal distension, gastroesophageal reflux, gastritis, ileus, inguinal hernia
GI perforation

(Summary – nausea and vomiting, pain, ulcerations, hernia, tearing of bowel, inflammation of vital organs)

Cardiovascular

Hemorrhage (up to 10%), hypertension (10%), hypotension (10%)
Cardiac failure
Congestive heart failure, tachycardia, arrhythmia, myocardial infarction, palpitations, vasculitis, sinus bradycardia, angina pectoris, thrombotic events

(Summary – haemorrhage, blood pressure, heart attack, clots and DEATH)

Nervous system

Headache (up to 12%)
Dizziness, nervousness
Cerebrovascular accident
Syncope, drowsiness, paresthesia, somnolence, tremors, convulsions, coma
Intraventricular hemorrhage, periventricular hemorrhage
Convulsions

(Summary – headache, neurological/psychiatric symptoms, stroke, seizure, coma, DEATH)

Renal

Increased blood urea (7%), renal insufficiency/impairment (6%), reduced urine output (3%), increased blood creatinine (3%), renal failure (1%), and increased blood urea with hematuria (1%).

Acute renal failure, renal papillary necrosis, interstitial nephritis, nephrotic syndrome, renal failure, renal insufficiency
Cystitis, azotemia, creatinine clearance decreased, glomerulitis, tubular necrosis, nephrotoxicity

(Summary – renal inflammation and infection, blood in urine, kidney failure, kidney disease and DEATH)

Hematologic

Bleeding events within 30 days of use in preterm infants was 32%. This percentage included grade 1 and 2 intraventricular hemorrhage (15%), grade 3 and 4 intraventricular hemorrhage (15%), and other bleeding (6%).

Anemia (up to 36%), eosinophilia (up to 26%), neutropenia (up to 13%), thrombocythemia (up to 10%)
Hemoglobin decreased
Leukopenia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, pancytopenia, hematocrit decreased
Lymphadenopathy, bleeding episodes

(Summary – anaemia (one of the most common causes), haemorrhage, lymphatic inflammation [common in lymphatic cancers], blood disorders)

Dermatologic

Rash, maculopapular rash, pruritus
Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis
Ecchymosis, purpura, alopecia, sweating, photosensitivity, angioedema, exfoliative dermatitis, urticaria, vesiculobullous eruptions, Henoch Schonlein vasculitis

(Summary – new diagnoses of skin diseases and inflammations)

Metabolic

Hypokalemia (up to 19%), hypoproteinemia (up to 13%), blood urea increased (10%), hypernatremia (10%), hypoalbuminemia (10%)
Appetite decreased, fluid retention
Appetite changes, hyperglycemia, hypoglycemic reaction, acidosis

(Summary – excretory processes impaired, poor appetite, fluid retention, inflammation, pain, high blood sugar [type II diabetes])

Other

Bacteremia (13%), blood LDH increased (up to 10%)
Peripheral edema, wound hemorrhage, tinnitus, hearing impairment, edema, fatigue
Aseptic meningitis, vertigo, exacerbation of infection-related inflammations
Fever, infection, sepsis, weight changes, asthenia, malaise, pseudo-tumor, hearing loss, drowsiness

(Summary – MENINGITIS, infections, hearing loss, fatigue, TUMOURS)

Respiratory

Bacterial pneumonia (up to 10%)
Cough
Asthma, bronchospasm, dyspnea, wheezing
Apnea, respiratory depression, pneumonia, rhinitis, epistaxis
Respiratory infection (19%), respiratory failure (10%), bronchopulmonary dysplasia
Atelectasis, pulmonary hemorrhage
Hypoxemia
Pulmonary hypertension

(Summary – pneumonia, asthma, loss of breath, haemorrhage)

Hepatic

Hepatitis, jaundice
Hepatorenal syndrome, liver necrosis, liver failure, abnormal liver function tests

(Summary – jaundice, hepatitis, liver disease)

Hypersensitivity

Hypersensitivity reactions have been reported and may consist of any of the following: a syndrome of abdominal pain, fever, chills, nausea, vomiting, and anaphylaxis; respiratory tract reactivity comprising bronchospasm, asthma/aggravated asthma, or dyspnea; skin reactions, which rarely included exfoliative and bullous dermatoses, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, pruritus, and urticaria.

(Summary – bullae, anaphylaxis, ulcerations, asthma, death of skin cells)

Ocular

Visual disturbances
Blurred vision, amblyopia, diminished vision, scotomata, changes in color vision, conjunctivitis, dry eyes, diplopia, optic neuritis, cataracts, optic neuritis, toxic optic neuropathy

(Summary – visual disturbances, poor vision, colour blindness, eye infections, dry eyes, cataracts, eye pain)

Musculoskeletal

Lupus erythematosus syndrome

(Summary – lupus)

Psychiatric

Anxiety, confusion, depression, dream abnormalities, insomnia, emotional disturbances, hallucinations

(Summary – psychiatric disorders, poor sleep, bad dreams, hallucinations, emotional issues)

Genitourinary

Urinary retention
Proteinuria, hematuria
Dysuria, oliguria, polyuria, menorrhagia

(Summary – UTI, painful periods, blood in urine)

Immunologic

Serum sickness

(Summary – increase of side effects of injected medications – ie vaccinations)

Endocrine

Gynecomastia

(Summary – man boobs)

Adrenal insufficiency

(Summary – adrenal fatigue, hormone imbalance)

References

1. “Product Information. Motrin (ibuprofen).” Pharmacia and Upjohn, Kalamazoo, MI.

2. Cerner Multum, Inc. “Australian Product Information.” O 0

3. “Product Information. Caldolor (ibuprofen).” Cumberland Pharmaceuticals Inc, Nashville, TN.

4. Cerner Multum, Inc. “UK Summary of Product Characteristics.” O 0

5. “Product Information. NeoProfen (ibuprofen).” Ovation Pharmaceuticals Inc, Deerfield, IL.

6. “Product Information. Ibuprofen (ibuprofen).” Par Pharmaceutical Inc, Spring Valley, NY.

7. Drugs.com

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Author: Chrysalis

Sharing the truth in health care with the public - especially those in nations where it is illegal to know the truth, for those who cannot afford health care, and for those who, through chronic illness or terminal disease are desperate to know the truth. And I will use any means necessary to do so. This has cost me dearly over the years - legally, professionally, financially and personally - but each time I feel as though it's not work it, I find I HAVE to keep going. After the recent loss of our adored son in law through medical negligence, I vowed to never give up the fight that I began in orthodox medicine, then as a naturopath seeing proof that there are answers outside of medicine, outside of surgery, toxic chemicals and big pharma's control - and when my daughter almost died through medical error. It's easy for some sectors of the community to dismiss someone who walked away from orthodox medicine. It's also easy for them to dismiss anyone who has qualifications in alternative medicine, regardless of how many lives they have saved - and regardless of whether most of those lives were failed by orthodoxy. Yet spend years in between, working in medical/pharma research and really get the inside story and then watch the worms come out of the woodwork. It's an interesting conundrum to see just how people who on the surface appear to be intellectual and reasonable, all of a sudden shoot off the Richter scale of common sense - after all, there is no way on earth someone who has a sound knowledge of facts, could possibly, actually know something they don't. Regardless of how my peers see me, I will spend the rest of my life getting the truth out there. It's astounding how much free time some of these poor excuses of humanity have, and how they believe they are discovering some amazing new thing with their hard hitting 'journalism' - imagine if all that effort could actually go into something decent and worthwhile.

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